Software Tutorials : Getting Started
Software Tutorials : Getting Started
Summary: A brief illustration of the most commonly used RCTdesign functions (seqDesign(), seqOC(), seqPlotBoundary(), seqPlotASN(), seqPlotPower()) when the primary statistical endpoint is the mean of a continuous random variable.
Commonly used probability models in RCT
Summary: An overview of the specification of commonly used probability models (mean, geometric mean, proportions, hazards) when designing RCT with seqDesign().
Summary: A description of the various scales that can be used to display stopping boundaries in RCTdesign. Choices include the scale of testimated treatment effect, the Z statistic, the fixed sample P value, the error spending function, conditional power, Bayesian predictive power, and Bayesian posterior probabilities.
Design families.
Summary: An overview of the specification of various group sequential design families implemented in RCTdesign. Choices include the Kittelson & Emerson (1999) unified family (including as special cases O’Brien-Fleming (1979); Pocock (1977); Whitehead & Stratton (1983) triangular designs; Wang & Tsiatis (1987); Emerson & Fleming (1989) symmetric designs; Pampallona & Tsiatis (1994)) and several Lan & DeMets (1983) error spending families (including Kim & DeMets (1987) power family; Hwang, Shih & DeCani (1990); Anderson & Clark (2006) logistic family).
Evaluation of designs: Producing and understanding tabular output
Summary: An overview of the various tables that are used to evaluate and compare clinical trial designs. Choices include tables of the stopping boundaries, accrual patterns (in time to event probability models), power, ASN, stopping probabilities, and inference.
Evaluation of designs: Producing and understanding plots
Summary: An overview of the various plots that are used to evaluate and compare clinical trial designs. Choices include plots of the stopping boundaries, accrual patterns (in time to event probability models), power, ASN, stopping probabilities, and inference.
Software Tutorial Topics:
•Specifying Hypotheses
•Nonbinding Futility
•Computing Sample Size
•Time to Event Accrual
•Sequential Sampling
•Stochastic Curtailment
•Unified Family
•Error Spending
•Constrained Boundaries
•Operating Characteristics
•Simulating RCTs
•Adaptive methods
•Inference
•Bayesian Evaluation
•Monitoring RCT
•Adaptive Designs
•Advanced Topics